Solutions by everydaycalculation.com
1st number: 1/6, 2nd number: 8 0/3
16 - 243 is -476.
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Related: 2/6-24/3 1/6-48/3 1/12-24/3 1/6-24/6 3/6-24/3 1/6-72/3 1/18-24/3 1/6-24/9 5/6-24/3 1/30-24/3 1/6-24/15 7/6-24/3 1/42-24/3 1/6-24/21
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