Solutions by everydaycalculation.com
1st number: 1/6, 2nd number: 21 1/3
16 - 643 is -1276.
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Related: 2/6-64/3 1/12-64/3 1/6-64/6 3/6-64/3 1/18-64/3 1/6-64/9 5/6-64/3 1/30-64/3 1/6-64/15 7/6-64/3 1/42-64/3 1/6-64/21
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