Solutions by everydaycalculation.com
1st number: 16/21, 2nd number: 3 9/12
1621 - 4512 is -25184.
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Related: 32/21-45/12 16/21-90/12 16/42-45/12 16/21-45/24 48/21-45/12 16/63-45/12 16/21-45/36 80/21-45/12 16/21-45/60 16/21-45/84
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