Solutions by everydaycalculation.com
1st number: 2/21, 2nd number: 1 11/21
221 - 3221 is -107.
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Related: 4/21-32/21 2/21-64/21 2/42-32/21 2/21-32/42 6/21-32/21 2/21-96/21 2/63-32/21 2/21-32/63 10/21-32/21 14/21-32/21
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