Solutions by everydaycalculation.com
1st number: 5/9, 2nd number: 2 3/21
59 - 4521 is -10063.
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Related: 10/9-45/21 5/9-90/21 5/18-45/21 5/9-45/42 15/9-45/21 5/27-45/21 5/9-45/63 25/9-45/21 5/45-45/21 35/9-45/21 5/63-45/21
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